Oncolytic activity of Newcastle disease virus strain zg1999hds on oral malignant melanoma in dog: A case report

Oral Malignant Melanoma (OMM) are the most frequent neoplasmsin dogs older than 10 years, and represent up to 7% of all malignant tumors in dog. Small breeds, with especially heavily pigmented oral mucosa greater risk get disease. The outcome OMM is related clinical stage at presentation e.g. tumor size, presence local or distant spread metastases, absence ulceration anatomic site. treatment consists radical resection primary tumor, considering behavior disease, radiotherapy, chemotherapy immunotherapy could be introduced. Other forms therapy such as using cytokines specific vaccine have also been tested controversial results. Oncolytic viruses not used dogs, although promising results melanomas humans were achieved. Described here efficacy NDV strain ZG1999HDS given locally systematically a dog OMM. After two sets virus application melanoma tissue had necrotized evident neutrophilic demarcation remnants viable cells which melanin pigmentation was no longer present.   &nbsp